Microbial Metabolite Urolithin B Inhibits Recombinant Human Monoamine Oxidase A Enzyme
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چکیده
منابع مشابه
Interactions of Desmethoxyyangonin, a Secondary Metabolite from Renealmia alpinia, with Human Monoamine Oxidase-A and Oxidase-B
Renealmia alpinia (Zingiberaceae), a medicinal plant of tropical rainforests, is used to treat snakebites and other injuries and also as a febrifuge, analgesic, antiemetic, antiulcer, and anticonvulsant. The dichloromethane extract of R. alpinia leaves showed potent inhibition of human monoamine oxidases- (MAOs-) A and B. Phytochemical studies yielded six known compounds, including pinostrobin ...
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Autophagy is an evolutionarily conserved pathway in which cytoplasmic contents are degraded and recycled. This study found that submicromolar concentrations of urolithin A, a major polyphenol metabolite, induced autophagy in SW620 colorectal cancer (CRC) cells. Exposure to urolithin A also dose-dependently decreased cell proliferation, delayed cell migration, and decreased matrix metalloprotein...
متن کاملThe relationship between human monoamine oxidase A and B
Monoamine oxidase (EC 1.4.3.4) exists in at least two forms (termed type A and type B) with different substrate and inhibitor specificities (Johnston, 1968; Knoll & Magyar, 1972). Amine neurotransmitters are among a wide range of substrates (Blaschko, 1974) and abnormalities of monoamine oxidase activity may therefore contribute to neurological disease. Most studies of such diseases have looked...
متن کاملHuman Plasma Monoamine Oxidase
Although this human plasma enzyme was shown (1) to have certain characteristics in common with plasma amine oxidases from other mammals (2-6), it could be distinguished from these other plasma enzymes by its substrate specificity. During studies relating to the substrate specificity of the human enzyme, the oxidation of aliphatic amines was noted to have a number of distinctive kinetic features...
متن کاملHuman Plasma Monoamine Oxidase
Amine oxidases that occur in the plasma of mammals have been intensively studied in recent years (l-8). The ability of human plasma and serum to convert benzylamine to benzaldehyde has recently been demonstrated (9). Evidence has been presented to show that this enzymatic activity is different from other human plasma enzymes that catalyze the oxidation of amines (i.e. ceruloplasmin and diamine ...
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ژورنال
عنوان ژورنال: Metabolites
سال: 2020
ISSN: 2218-1989
DOI: 10.3390/metabo10060258